Department of Biology
Colorado State University, Department of Biology
Louisiana State University, Department of Biological Sciences
San Diego State University, Department of Biology
Texas A & M University
Courses Taught at Fredonia
Bio 336 – Mammalian Physiology
Research Interests – Skeletal Muscle Structure and Function
My research focus is on the cellular and molecular organization of skeletal muscles and how these properties change in response to development, exercise, and other demands. The physiological properties of muscles are primarily derived from their cellular and molecular organization. All muscle work is based on muscle shortening, produced when myosin heavy chain (MHC) motors bind to actin filaments and pull them. Yet within this common design, great diversity exists with respect to cellular organization and function. I am particularly interested in the organization of skeletal muscles from the standpoint of task-specific design, and the integration with organismal function. Muscles differ with respect to their specific assemblage of myofibrillar protein isoforms, including multiple isoforms of motor proteins (myosins) and of the regulatory proteins (tropomyosin and troponins I, T, and C) that function to switch the muscle on and off. Structural features, such as sarcomere width, also represent design parameters that affect muscle function. In my lab we work to understand how these various parameters are matched with one another to create a specific muscle phenotype. We are currently studying single fibers co-expressing two or more MHC isoforms (hybrid fibers) and their role in mammalian muscle plasticity. We are also studying skeletal muscles in running ghost crabs, with the goal of understanding how these muscles power rapid running.
Denies M, Johnson, J, Maliphol, AB, Bruno, M, Kim, A, Rizvi, A, Rustici, K, and Medler, S. (in review). Diet induced obesity alters skeletal muscle fiber types of male but not female mice.
Medler S, and Harrington, F (in press) Measuring dynamic kidney function in an undergraduate physiology laboratory.Advances in Physiology Education 37.
Brummer H, Zhang MY, Piddoubny M, and Medler S (in press) Hybrid fibers transform into distinct fiber types in maturing mouse muscles. Cells Tissues and Organs.
Zhang, MY, Zhang, WJ, and Medler, S (2010). The continuum of IIX/IIB hybrid fibers in normal mouse muscles: relative proportions and distribution of isoforms. American Journal of Physiology Regulatory Integrative Comp Physiol 299: R1582-R1591.
Glaser, BW, You, G, Zhang, M, and Medler, S. (2010). Relative proportions of hybrid
Perry, MJ, Tait, J, Hu, J, White, SC, and Medler, S. (2009). Skeletal muscle fiber types in the ghost crab, Ocypode quadrata: implications for running performance. Journal of Experimental Biology 212: 673-683.
Medler, S and Hulme, K (2009). Power output from striated muscles performing cyclical contractions: patterns and constraints. Comparative Biochemistry and Physiology 152A: 407-417.
Medler, S, Lilley, TR, Riehl, JH, Mulder, EP, Chang, ES, and Mykles, DL (2007). Myofibrillar gene expression in differentiating lobster claw muscles. Journal of Experimental Zoology 307A: 281-295.