Dr. Scott Medler

Scott MedlerScott Medler

Assistant Professor

Department of Biology
226 Jewett Hall
The State University of New York at Fredonia
Fredonia, NY  14063

E-mail: scott.medler@fredonia.edu
Phone: (716) 673-3360
Fax: (716) 673-3493

 

 

 

 

 

Education 

Colorado State University, Department of Biology
NIH Postdoctoral Fellow: 2000 – 2003 

Louisiana State University, Department of Biological Sciences
PhD: 1998 

San Diego State University, Department of Biology
MS candidate: 1989 - 1992 

Texas A & M University
BS Zoology: 1989 

Courses Taught at Fredonia

Bio 336 – Mammalian Physiology
Bio 337 – Mammalian Physiology Lab
Bio 450 – Comparative Anatomy
Bio 450 – Muscles and Movement
Bio 110 – Human Biology

 

Research Interests – Skeletal Muscle Structure and Function

My research focus is on the cellular and molecular organization of skeletal muscles and how these properties change in response to development, exercise, and other demands. The physiological properties of muscles are primarily derived from their cellular and molecular organization. All muscle work is based on muscle shortening, produced when myosin heavy chain (MHC) motors bind to actin filaments and pull them. Yet within this common design, great diversity exists with respect to cellular organization and function. I a­­­­m particularly interested in the organization of skeletal muscles from the standpoint of task-specific design, and the integration with organismal function. Muscles differ with respect to their specific assemblage of myofibrillar protein isoforms, including multiple isoforms of motor proteins (myosins) and of the regulatory proteins (tropomyosin and troponins I, T, and C) that function to switch the muscle on and off. Structural features, such as sarcomere width, also represent design parameters that affect muscle function.  In my lab we work to understand how these various parameters are matched with one another to create a specific muscle phenotype.  We are currently studying single fibers co-expressing two or more MHC isoforms (hybrid fibers) and their role in mammalian muscle plasticity. We are also studying skeletal muscles in running ghost crabs, with the goal of understanding how these muscles power rapid running. 

 

Recent Publications

Denies M, Johnson, J, Maliphol, AB, Bruno, M, Kim, A, Rizvi, A, Rustici, K, and Medler, S. (2014).  Diet induced obesity alters skeletal muscle fiber types of male but not female mice.  Physiolgical Reports 2: e00204.

Medler S, and Harrington, F (2013) Measuring dynamic kidney function in an undergraduate physiology laboratory.  Advances in Physiology Education 37: 384-391.

Brummer H, Zhang MY, Piddoubny M, and Medler S (2013) Hybrid fibers transform into distinct fiber types in maturing mouse muscles. Cells Tissues and Organs 198: 227-236.

Zhang, MY, Zhang, WJ, and Medler, S (2010). The continuum of IIX/IIB hybrid fibers in normal mouse muscles: relative proportions and distribution of isoforms. American Journal of Physiology Regulatory Integrative Comp Physiol 299: R1582-R1591. 

Glaser, BW, You, G, Zhang, M, and Medler, S. (2010). Relative proportions of hybrid
fibers are unaffected by 6 weeks of running exercise in mouse skeletal muscles. Experimental Physiology 95: 211-221. 

Perry, MJ, Tait, J, Hu, J, White, SC, and Medler, S. (2009). Skeletal muscle fiber types in the ghost crab, Ocypode quadrata: implications for running performance. Journal of Experimental Biology 212: 673-683. 

Medler, S and Hulme, K (2009). Power output from striated muscles performing cyclical contractions: patterns and constraints. Comparative Biochemistry and Physiology 152A: 407-417. 

Medler, S, Lilley, TR, Riehl, JH, Mulder, EP, Chang, ES, and Mykles, DL (2007). Myofibrillar gene expression in differentiating lobster claw muscles. Journal of Experimental Zoology 307A: 281-295.


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